LINKIng gut bacteria and joint inflammation in IBD
2024
Lima SF, Pires S, Rupert A, Oguntunmibi S, Jin WB, Marderstein A, Funez-dePagnier G, Maldarelli G, Viladomiu M, Putzel G, Yang W, Tran N, Xiang G, Grier A, Guo CJ, Lukin D, Mandl LA, Scherl EJ, Longman RS. The gut microbiome regulates the clinical efficacy of sulfasalazine therapy for IBD-associated spondyloarthritis. Cell Rep Med. 2024 Mar 19;5(3):101431. doi: 10.1016/j.xcrm.2024.101431. Epub 2024 Feb 19. PMID: 38378002
2023
Hill AA, Kim M, Zegarra-Ruiz DF, Chang LC, Norwood K, Assié A, Wu WH, Renfroe MC, Song HW, Major AM, Samuel BS, Hyser JM, Longman RS, Diehl GE. Acute high-fat diet impairs macrophage-supported intestinal damage resolution. JCI Insight. 2023 Feb 8;8(3):e164489. doi: 10.1172/jci.insight.164489. PMID: 36538527
Rajan A, Pan Y, Mahtani P, Niec R, Longman R, Gerber J, Lukin D, Scherl E, Battat R. The Impact of Confounders on Symptom-Endoscopic Discordances in Crohn's Disease. Crohns Colitis 360. 2023 Mar 28;5(2):otad017. doi: 10.1093/crocol/otad017. eCollection 2023 Apr. PMID: 37016720
Van NT, Zhang K, Wigmore RM, Kennedy AI, DaSilva CR, Huang J, Ambelil M, Villagomez JH, O'Connor GJ, Longman RS, Cao M, Snook AE, Platten M, Kasenty G, Sigal LJ, Prendergast GC, Kim SV. Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15. Nat Commun 2023 Nov 14;14(1):7363. doi: 10.1038/s41467-023-43211-4. PMID: 37963876
Hassan-Zahraee M, Ye Z, Xi L, Dushin E, Lee J, Romatowski J, Leszczyszyn J, Danese S, Sandborn WJ, Banfield C, Gale JD, Peeva E, Longman RS, Hyde CL, Hung KE. Baseline serum and stool microbiome biomarkers predict clinical efficacy and tissue molecular response after ritlecitinib induction therapy in ulcerative colitis. J Crohns Colitis 2023 Dec 23:jjad213. doi: 10.1093/ecco-jcc/jjad213. PMID: 38141256
2022
Jin WB, Li TT, Huo D, Qu S, Li XV, Arifuzzaman M, Lima SF, Shi HQ, Wang A, Putzel GG, Longman RS, Artis D, Guo CJ. Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome. Cell. 2022 Feb 3;185(3):547-562.e22. PMID: 35051369
Battat R, Galati JS, Lukin D, Chabouni F, Sockolow R, Carter J, Fajardo K, Yang S, Reich J, Jacobs V, Abramowitz M, Kumar A, Christos P, Longman RS, Burakoff R, Simone L, Sapir T, Crawford CV, Scherl EJ. A Quality Improvement Initiative Is Associated With Reduced Time to Administer Biologics and Small Molecules and Emergency Room Visits in Inflammatory Bowel Disease. J Clin Gastroenterol. 2022 Mar 1;56(3):e176-e182. PMID: 35180182
Paik D, Yao L, Zhang Y, Bae S, D'Agostino GD, Zhang M, Kim E, Franzosa EA, Avila-Pacheco J, Bisanz JE, Rakowski CK, Vlamakis H, Xavier RJ, Turnbaugh PJ, Longman RS, Krout MR, Clish CB, Rastinejad F, Huttenhower C, Huh JR, Devlin AS. Human gut bacteria produce Τ Η 17-modulating bile acid metabolites. Nature. 2022 Mar 16. doi: 10.1038/s41586-022-04480-z. PMID: 35296854
Lai D, Funez-Depagnier G, Duenas-Bianchi L, Lavergne A, Battat R, Ahmed W, Schwartzman M, Lima S, Khan S, Chong PS, Sonnenberg G, Artis D, Lukin D, Scherl E, Longman RS. Joint Disease Activity in Inflammatory Bowel Disease-associated Peripheral Spondyloarthritis Stratifies Therapeutic Response. Gastro Hep Adv. 2022;1(2):137-140. doi: 10.1016/j.gastha.2021.12.002. Epub 2022 Feb 7. PMID: 35441160. PMCID: PMC9015680
Angkeow JW, Monaco DR, Chen A, Venkataraman T, Jayaraman S, Valencia C, Sie BM, Liechti T, Farhadi PN, Funez-dePagnier G, Sherman-Baust CA, Wong MQ, Ruczinski I, Caturegli P, Sears CL, Simner PJ, Round JL, Duggal P, Laserson U, Steiner TS, Sen R, Lloyd TE, Roederer M, Mammen AL, Longman RS, Rider LG, Larman HB. Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses. Immunity. 2022 May 27:S1074-7613(22)00222-9. doi: 10.1016/j.immuni.2022.05.002. PMID: 35649416
Zhang S, Morgan X, Dogan B, Martin FP, Strickler S, Oka A, Herzog J, Liu B, Dowd SE, Huttenhower C, Pichaud M, Dogan EI, Satsangi J, Longman R, Yantiss R, Mueller LA, Scherl EJ, Sartor RB, Simpson KW. Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn's disease. JCI Insight. 2022 May 23;7(10):e157013. doi: 10.1172/jci.insight.157013. PMID: 35413017
Zegarra Ruiz DF, Kim DV, Norwood K, Saldana-Morales FB, Kim M, Ng C, Callaghan R, Uddin M, Chang LC, Longman RS, Diehl GE. Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer. Gut Microbes. 2022 Jan-Dec;14(1):2119054. doi: 10.1080/19490976.2022.2119054. PubMed PMID: 36062329; PubMed Central PMCID: PMC9450902.
Viladomiu M, Khounlotham M, Dogan B, Lima SF, Elsaadi A, Cardakli E, Castellanos JG, Ng C, Herzog J, Schoenborn AA, Ellermann M, Liu B, Zhang S, Gulati AS, Sartor RB, Simpson KW, Lipkin SM, Longman RS. Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis. Cell Rep. 2022 Nov 15;41(7):111637. doi: 10.1016/j.celrep.2022.111637. PMID: 36384110
Battat R, Scherl EJ, Lukin D, Charilaou P, Mahtani P, Gerber J, Gandara JA; JRI Live Cell Bank, Dündar F, Zumbo P, Betel D, Guo CJ, Longman RS. Increased Primary Bile Acids with Ileocolonic Resection Impact Ileal Inflammation and Gut Microbiota in Inflammatory Bowel Disease. J Crohns Colitis. 2022 Nov 2:jjac173. doi: 10.1093/ecco-jcc/jjac173. PMID: 36322790
Gordon BL, Galati JS, Yang S, Longman RS, Lukin D, Scherl EJ, Battat R. Prevalence and factors associated with vitamin C deficiency in inflammatory bowel disease. World J Gastroenterol. 2022 Sep 7;28(33):4834-4845. doi: 10.3748/wjg.v28.i33.4834. PMID: 36156920
Porras AM, Zhou H, Shi Q, Xiao X; JRI Live Cell Bank; Longman R, Brito IL. Inflammatory Bowel Disease-Associated Gut Commensals Degrade Components of the Extracellular Matrix. mBio. 2022 Dec 20;13(6):e0220122. doi: 10.1128/mbio.02201-22. Epub 2022 Nov 29. PMID: 36445085
2021
Lima SF, Gogokhia L, Viladomiu M, Chou L, Putzel G, Jin WB, Pires S, Guo CJ, Gerardin Y, Crawford CV, Jacob V, Scherl E, Brown SE, Hambor J, Longman RS. (2022). Transferable immunoglobulin A–coated odoribacter splanchnicus in responders to fecal microbiota transplantation for ulcerative colitis limits colonic inflammation. Gastroenterology, 162(1), 166–178. https://doi.org/10.1053/j.gastro.2021.09.061
Viladomiu M, Metz ML, Lima SF, Jin WB, Chou L, Guo CJ, Diehl GE, Simpson KW, Scherl EJ, Longman RS. (2021). Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation. Cell Host & Microbe, 29(4). https://doi.org/10.1016/j.chom.2021.01.002
2019
Castellanos JG, Longman RS. The balance of power: Innate lymphoid cells in tissue inflammation and repair. Journal of Clinical Investigation. 2019 Jun 10;129(7):2640-2650. doi: 10.1172/JCI124617. PMID: 31180335
Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, O'Connell R, Jacob V, Scherl E, Crawford C, Stephens WZ, Casjens SR, Longman RS, Round JL. Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Cell Host Microbe. 2019 Feb 13;25(2):285-299.e8. doi: 10.1016/j.chom.2019.01.008. PMID: 30763538
2018
Castellanos JG, Woo V, Viladomiu M, Putzel G, Lima S, Diehl GE, Marderstein AR, Gandara J, Perez AR, Withers DR, Targan SR, Shih DQ, Scherl EJ, Longman RS. Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis. Immunity. 2018 Dec 5. pii: S1074-7613(18)30479-5. doi: 10.1016/j.immuni.2018.10.014. PMID: 30552020
Kim M, Galan C, Hill AA, Wu WJ, Fehlner-Peach H, Song HW, Schady D, Bettini ML, Simpson KW, Longman RS, Littman DR, Diehl GE. Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses. Immunity. 2018 Jul 17;49(1):151-163.e5. doi: 10.1016/j.immuni.2018.05.009. PMID: 29980437
2017
Kim S, Kim H, Yim YS, Ha S, Atarashi K, Tan TG, Longman RS, Honda K, Littman DR, Choi GB, Huh JR. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature. 2017 Sep 28;549(7673):528-532. doi: 10.1038/nature23910. PMID: 28902840
Blander JM, Longman RS, Iliev ID, Sonnenberg GF, Artis D. Regulation of inflammation by microbiota interactions with the host. Nat Immunol. 2017 Jul 19;18(8):851-860. doi: 10.1038/ni.3780. Review. PMID: 28722709
Jacob V, Crawford C, Cohen-Mekelburg S, Viladomiu M, Putzel GG, Schneider Y, Chabouni F, OʼNeil S, Bosworth B, Woo V, Ajami NJ, Petrosino JF, Gerardin Y, Kassam Z, Smith M, Iliev ID, Sonnenberg GF, Artis D, Scherl E, Longman RS. Single Delivery of High-Diversity Fecal Microbiota Preparation by Colonoscopy Is Safe and Effective in Increasing Microbial Diversity in Active Ulcerative Colitis. Inflamm Bowel Dis. 2017 Jun;23(6):903-911. doi: 10.1097/MIB.0000000000001132. PMID: 28445246
Viladomiu M, Kivolowitz C, Abdulhamid A, Dogan B, Victorio D, Castellanos JG, Woo V, Teng F, Tran NL, Sczesnak A, Chai C, Diehl GE, Ajami N, Petrosino J, Zhou XK, Schwartzman S, Mandl L, Abramowitz M, Jacob V, Bosworth B, Steinlauf A, Scherl EJ, Wu HJ, Simpson KW, Longman RS. Functional characterization of IgA-targeted E. coli in Crohn’s Disease-associated Spondyloarthritis Links Mucosal Immunity with Systemic Inflammation. Sci Transl Med 2017; 9 (376), pii:eaaf9655. Doi:10.1126/scitranslmed.aaf9655. PMID 28179509. Click here for a reprint of this manuscript.
2015
Hirten R, Longman RS, Bosworth BP, Steinlauf A, Scherl E. Vedolizumab and Infliximab Combination Therapy in the Treatment of Crohn's Disease. Am J Gastroenterol. 2015 Dec;110(12):1737-8. doi: 10.1038/ajg.2015.355. PMID: 26673509
Chen H, Sun J, Huang Z, Hou H, Arcilla M, Rakhilin N, Joe D, Choi J, Gadamsetty P, Milsom J, Nandakumar G, Longman RS, Zhou K, Edwards R, Chen J, Chen K, Bu P, Miller A, Gümüs Z, Shuler M, Nishimura N, Edelmann W, Shen X, Lipkin SM. Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer. Nature Biotechnology 2015 Jun; 33(6):656-60. doi: 10.1038/nbt.3239
Longman RS, Littman DR. The functional impact of the intestinal microbiome on mucosal immunity and systemic autoimmunity. Curr Opin Rheumatol. 2015 Jul;27(4):381-7. doi: 10.1097/BOR.0000000000000190. Review. PMID: 26002030
2014
Longman RS, Diehl G, Victorio D, Huh J, Miraldi E, Swaminath A, Bonneau R, Scherl EJ, Littman DR. CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med 211, 1571-1583, doi:10.1084/jem.20140678 (2014). # Co-corresponding authors
Longman RS, Scherl EJ. Medical Management of Extraintestinal Manifestations of Ulcerative Colitis. In G. Lichtenstein (Ed.), Medical Therapy of Mucosal Ulcerative Colitis, New York: Springer, (2014).
2013
Scher JU*, Sczesnak A*, Longman RS*, Segata N, Ubeda C, Bielski C, Rostron T, Cerundolo V, Pamer EG, Abramson SB, Huttenhower C, Littman DR. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife 2013;2:e01202. Doi: 10.7554/eLife.01202 *Contributed equally
Longman RS, Yang Y, Diehl GE, Kim SW, Littman DR. Microbiota-Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity, Cold Spring Harb Symp Quant Biol (2013), 78:193-201. PMCID: PMC4367195
Diehl G, Longman RS, Zhang J, Breart B, Galan C, Cuesta A, Schwab S, Littman DR. Microbiota-Derived Signals Limit CX3CR1+ Cell-Dependent Trafficking of Bacteria to the Mesenteric Lymph Nodes. Nature, Feb 7;494(7435):116-20. doi: 10.1038/nature11809. Epub 2013 Jan 13. PubMed PMID: 23334413.
Pre-2012
Decalf J, Fernandes S, Longman R, Aloulay M, Audat F, Lefrerre F, Rice CM, Pol S, Albert ML. Plasmacytoid DCs initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients. J. Exp. Med., 204: 2423-2437 (2007). PMCID: PMC2118448
Longman RS, Pellegrini S, Rice CM, Darnell RB, Albert ML. Dendritic cell maturation alters intracellular signaling networks, enabling differential effects of IFNa/b on antigen cross-presentation. Blood 109: 1113-1122 (2007). PMID: 17018853
Barba-Spaeth G*, Longman RS*, Albert ML, Rice CM. Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes. J. Exp Med. 202:1179-1184 (2005). PMCID: PMC2213233 *Contributed equally
Longman RS, Talal A, Jacobson I, Rice CM, Albert ML. Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patient with chronic hepatitis C. J. Infect. Dis. 192: 497-503 (2005). PMID: 15995965
Braun D, Longman RS, Albert ML. A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation. Blood 106:2375-2381 (2005). PMCID: PMC1895261
Longman RS, Talal A, Jacobson I, Albert ML, Rice CM. Presence of functional dendritic cells in patients chronically infected with hepatitis C virus. Blood 103:1026-1029 (2004). PMID: 14525790
Stathopoulos C, Jacquin-Becker C, Becker HD, Li T, Ambrogelly A, Longman RS, Söll D. Methanococcus jannaschii prolyl-cysteinyl-tRNA synthetase possesses overlapping amino acid binding sites. Biochemistry 40: 46-52 (2001). PMID: 11141055
Stathopoulos C, Li T, Longman RS, Vothknecht UC, Becker H, Ibba M, Söll D. One polypeptide with two aminoacyl-tRNA synthetase activities. Science 287: 479-482 (2000). PMID: 1064254